Additional Information

Description

Nitro Pmix (D5W) 50 mg/250 mL is a sterile intravenous solution containing nitroglycerin at a concentration of 50 mg diluted in 250 mL of 5% dextrose in water (D5W). It is primarily used as a vasodilator in the management of acute angina, heart failure, and conditions requiring controlled reduction of blood pressure, such as hypertensive emergencies.

This formulation provides a precise and continuous delivery of nitroglycerin when administered via an infusion pump. The solution is prepared in a sterile, preservative-free, ready-to-use format, minimizing the risk of contamination and simplifying preparation for healthcare professionals. The inclusion of 5% dextrose in water serves as the diluent and provides additional energy substrate during administration.

Nitroglycerin acts by releasing nitric oxide, which stimulates the enzyme guanylate cyclase in vascular smooth muscle cells, leading to increased cyclic GMP levels. This process causes relaxation of the vascular smooth muscles, resulting in decreased preload and afterload, improved myocardial oxygen supply, and reduced cardiac workload.